No question about it — it’s a long way across South Dakota! If you take Interstate 90, there’s 410 miles worth of South Dakota between Minnesota and Wyoming… 410 miles of vacation fun, if you know what’s coming your way. Cites & Towns Located in the I-90 East Region Cities & Towns Mitchell Cities & Towns Murdo Cities & Towns Wall Things to See & Do in the I-90 East Region Outdoor Recreation Photography Outdoor Recreation Geocaching
