No question about it — it’s a long way across South Dakota! If you take Interstate 90, there’s 410 miles worth of South Dakota between Minnesota and Wyoming… 410 miles of vacation fun, if you know what’s coming your way. Cites & Towns Located in the I-90 East Region Cities & Towns Wall Cities & Towns Mitchell Cities & Towns Murdo Things to See & Do in the I-90 East Region Outdoor Recreation Geocaching Outdoor Recreation Photography
